Design and synthesis of novel cytotoxic fluoroquinolone analogs through topoisomerase inhibition, cell cycle arrest, and apoptosis

HIGHLIGHTS

  • who: Mohamed A. Elanany from the DepartmentBadr University have published the article: Design and synthesis of novel cytotoxic fluoroquinolone analogs through topoisomerase inhibition, cell cycle arrest, and apoptosis, in the Journal: Scientific Reports Scientific Reports
  • what: We designed and synthesized a series of FQ-based cytotoxic agents by functionalizing the acid hydrazides of three clinically approved FQ drugs (moxifloxacin, ofloxacin, and ciprofloxacin).

SUMMARY

    NCI‑60 human tumor cell lines screen single‑dose assay. For comparative analysis of the single-dose assay data, a graphical heat map was constructed using the percentage . . .

     

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