HIGHLIGHTS
SUMMARY
Since PARP1 was found to be a key player in the repair of trapped TOP1cc by TDP1, the authors investigated the influence of these compounds separately and in combination with the gene_expression of the wild_type and PARP1-knockout (PARP1-KO) cells. The expression level of DNA glycosylases genes (NEIL1, SMUG1, MPG, NEIL3), and DNA_polymerases or their subunits genes (POLE4, POLD2, POLD4, POLB) decreased. DNA_polymerases δ and ε are replicative polymerases that are responsible for the synthesis of the lagging (DNA_polymerase δ), or the leading (DNA_polymerase ε) strand. FEN1 inhibits strand displacement DNA synthesis catalyzed by DNA_polymerase δ, but stimulates . . .
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