Gastrointestinal cancer-associated fibroblasts expressing junctional adhesion molecule-a are amenable to infection by oncolytic reovirus

HIGHLIGHTS

• who: Tom J. Harryvan from the interest to study the natural tropism of wildtype or bioselected OVs towards CAFsNatural GI CAF tropism has currently only been described for vesicular-stomatitis virus (VSV), but this virus is mostly studied in the pre-clinical setting [1, ]. Therefore, we investigated the tropism of two commonly used OVs, adenovirus and reovirus, towards primary GI fibroblasts derived from human oesophageal, gastric, duodenal and pancreatic carcinomas. We show that GI fibroblasts are susceptible to type , Dearing (T D) strain , and bioselected mutant reovirus (jin-3) infection but not adenovirus (Ad5-u039424). Therefore, we . . .
  

   

  

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