HIGHLIGHTS
SUMMARY
Screening of DNA-encoded libraries (DELs) have facilitated the discovery of small_molecule ligands. Despite the success of small_molecule chemotherapies to inhibit oncoproteins, it is notable that only 3,000 out of ~25,000 proteins encoded by the human genome possess binding_sites suitable to interact with small_molecules. For instance, protein-protein interactions (PPIs), which are critical to tumorigenesis and metastatic pathways due to the high cellular compartmentalization are highly challenging even as binding targets for small_molecules because of the featureless nature of protein interfaces. Small or short peptides are a very interesting class of pharmaceutical . . .
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