HIGHLIGHTS
- who: Jing Jiang from the School Chengdu University have published the Article: Silver/chiral pyrrolidinopyridine relay catalytic cycloisomerization/(2u280b+u280b3) cycloadditions of enynamides to asymmetrically synthesize bispirocyclopentenes as PDE1B inhibitors, in the Journal: (JOURNAL) of 28/02/2023
- what: The authors report a system involving silver acetate and a modified chiral PPY which can efficiently catalyze the unreported cycloisomerization/(2 + 3) cycloadditions of enynamides (Fig 1C).
- how: Adjusting the substituents on the phenyl groups of Connon`s catalyst C1 influenced reaction efficiency and enantioselectivity while only moderate results were obtained. To provide insights . . .
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