HIGHLIGHTS
- who: Daniel Englert from the (UNIVERSITY) have published the research: Fast-exchanging spirocyclic rhodamine probes for aptamer-based super-resolution RNA imaging, in the Journal: (JOURNAL) of 22/06/2023
- what: The authors report the development of RhoBAST:SpyRho, a fluorescent light-up aptamer (FLAP) system ideally suited for visualizing RNAs in live or fixed cells with various advanced fluorescence microscopy modalities. Overcoming problems associated with low cell permeability, brightness, fluorogenicity, and signal-to-background ratio of previous fluorophores, the authors design a novel probe, SpyRho (Spirocyclic Rhodamine), which tightly binds to the RhoBAST aptamer . . .
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