Systematic prediction of degrons and e3 ubiquitin ligase binding via deep learning

HIGHLIGHTS

• who: Chao Hou from the (UNIVERSITY) have published the article: Systematic prediction of degrons and E3 ubiquitin ligase binding via deep learning, in the Journal: (JOURNAL)
• what: Specifically, the authors focused on recurrent mutations (>=two tumor samples) which are more pathologically significant and tend to occur in degron-related regions (Fig 6b). The work provides novel insights for explaining how a specific subset of driver mutations affect the degradation of proteins and helps bridge the gap between cancer genomics to proteomics.
• how: The authors developed a deep learning-based model named Degpred that . . .
  

   

  

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