HIGHLIGHTS
SUMMARY
E2F proteins are a family of transcription factors (TFs), involved in the Retinoblastoma (Rb)-dependent pathway that control cell cycle progression by orchestrating a precise pattern of gene_expression. The authors constructed a model to explain ATCs origin integrating gene_expression microarray data from different studies. The authors found E2F7 as master regulator coordinating this non-canonical, context specific, pro-oncogenic gene_expression program fundamental for ATC aggressiveness and progression, defining a crucial step in DTC to ATC evolution. The authors explored the causal relationship between DTC and ATC using gene_expression data. The authors analyzed 279 gene_expression . . .
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