Bmal1/p53 mediating bronchial epithelial cell autophagy contributes to pm2.5-aggravated asthma

HIGHLIGHTS

• who: Shuai-Jun Chen from the sgRNA and Cas, mRNA were injected into the fertilized mouse eggsCas, nuclease and sgRNA bound to the mouse genome target sequence Bmal, and cut the double-stranded DNA, and then the Bmal, gene was subjected to frameshift mutation or fragment knockout by the non-homologous end joining repair. Bmal1-KO (Bmal1-/-) mice and Bmal1-WT (Bmal1wt/wt) mice were bred at Cyagen (Cyagen Biosciences, Guangzhou, China). All animal experiments involving mice were approved by the Institutional Animal Care and Use Committee of Tongji Medical College, Huazhong University of Science and Technology . . .
  

   

  

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