Impaired autophagy-accelerated senescence of alveolar type ii epithelial cells drives pulmonary fibrosis induced by single-walled carbon nanotubes

HIGHLIGHTS

• who: Xiang Zhang from the Eight-week-old female C BL/ J mice were obtained from the Laboratory Animal Centre of Anhui Medical UniversityAll mice were maintained in a standard environment for , week. To examine the effect of SWCNTs on autophagy and cellular senescence in AECIIs at different stages, the mice were administered a single dose of , u03bcg SWCNTs in , u03bcl of PBS by intratracheal instillation, and mice in the control (CTRL) group were treated with , u03bcl PBS. This dose has been shown to be relevant to human exposures at workplace [32]. The characteristics of SWCNTs were . . .
  

   

  

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