HIGHLIGHTS
- who: . et al. from the The Pennsylvania State University (PSU), United States have published the paper: Inference of gene-environment interaction from heterogeneous case-parent trios, in the Journal: (JOURNAL)
- what: The authors show that current methods to reduce the bias in estimated geneenvironment interactions from case-parent trio data can only account for simple population structure involving two strata. To fill this gap, the authors propose to directly accommodate multiple population strata by adjusting for genetic principal components (PCs). And Discussion: Through simulations, the authors show that the PC adjustment maintains the nominal type . . .
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