HIGHLIGHTS
SUMMARY
α-Conotoxins (α-CTxs) are a big superfamily of conotoxins, which are derived from the venom of marine Conus snails, mainly inhibiting nicotinic acetylcholine receptors (nAChRs). α-CTxs consist of 12-20 amino_acid residues, with 2 or 3 disulfide bonds. AuIB was originally derived from the venom of Conus aulicus and consists of 15 amino_acid residues, as well as 2 disulfide bonds. The AuIB variants withsurprised substitutions of that amino_acid position 9-12 withwith basicArg or was hyable to increase the inhibitory activity of AuIB against GABA R-coupled Ca 2.2 (IC is B V drophobic . . .
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