New therapeutics for heart failure: focusing on cgmp signaling

HIGHLIGHTS

  • who: Supachoke Mangmool et al. from the Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand have published the paper: New Therapeutics for Heart Failure: Focusing on cGMP Signaling, in the Journal: (JOURNAL)
  • what: The phase II COSMIC-HF trial aimed to investigate the pharmacokinetic (PK) effects of omecamtiv on cardiac function and structure in HFrEF patients . The study showed no significant differences in NT-proBNP levels and LAV between vericiguat and placebo groups. The results of the study showed that, compared with the placebo, vericiguat did not lead to any improvement in the . . .

     

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