Leukotriene a4 hydrolase (lta4h rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis

HIGHLIGHTS

  • who: Selwyn Selva Kumar from the Department have published the article: Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis, in the Journal: Scientific Reports Scientific Reports
  • what: The study shows TT genotype had a trend towards lesser culture positivity (16.7%) compared to hypo-inflammatory CC type (23.1%), suggesting the potential role of hyper-inflammatory TT genotype in restricting mycobacterial replication, probably due to excessive inflammation . The International Network for the Study of HIV-associated Immune reconstitution inflammatory syndrome (INSHI) consensus case definition was used to define u00adPRs17.
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