HIGHLIGHTS
SUMMARY
The dynamics of negative selection are well recognized, but prior investigations across multiple cancer types found few genes are broadly conserved (Martincorena et_al, 2018; Zapata et_al, 2018). Computer simulations demonstrated evolutionary conservation in cancer populations varies depending on local tissue environment selection forces and prior molecular changes in their evolutionary arc (Gatenby et_al, 2014; Cunningham et_al, 2015). Antigen presentation, immune-modulating protein expression (e_g, checkpoint ligands), as well as cytokine and chemokine secretion by epithelial_cells can promote or reduce host immune functions (Schleimer et_al, 2007; Larsen et_al, 2020). Epithelial_cells express surface and cytoplasmic pattern_recognition . . .
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