A risk model developed based on necroptosis to assess progression for ischemic cardiomyopathy and identify possible therapeutic drugs

HIGHLIGHTS

SUMMARY

    Left ventricular systolic dysfunction is an independent predictor of adverse outcomes in patients with HF (Calderon-Dominguez et_al, 2021). Necroptosis is a type of non-apoptotic programmed cell death pathway, also called autophagy-induced cell death, which show have play an important role in the immune systems (Khoury et_al, 2020; Bertheloot et_al, 2021). The CMap (https://clue.io/) (Musa et_al, 2018), a webbased database that exploits differences in gene_expression following treatment of human cells with different disruptors to create a database of biological applications where smallmolecule compounds, gene_expression and disease are interrelated. Tofacitinib or . . .

     

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