HIGHLIGHTS
- who: Pedro Latorre-Muro from the (UNIVERSITY) have published the research work: Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity, in the Journal: (JOURNAL) of July/26,/2020
- what: The authors report that p300 weakly acetylates PCK1, but surprisingly, using several techniques including protein_crystallization, mass spectrometry, isothermal titration calorimetry, saturationtransfer difference nuclear magnetic_resonance and molecular docking, the authors found that PCK1 is also able to acetylate itself using acetyl-CoA independently of p300. The authors investigate the mechanism and molecular consequences of PCK1 self-acetylation. The authors demonstrate that residues . . .
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