HIGHLIGHTS
- who: Evelyne Gout from the be needed to assess the functional relevance of the potential interactions of, ficolin with sialic acid-bearing pathogens and malignant cellsIn conclusion glycan array screening of the three human ficolins shows that, and, ficolin have different recognition specificities and confirms the poor lectin activity of, ficolin. Novel ligands are revealed, such as sulfated, acetyllactosamine for, ficolin and gangliosides for, ficolin. Moreover, we show that, ficolin has high specificity for, acetylated sialic acid in an ␣2, linkage to galactose, which is a relatively rare specificity. Indeed, although sialic acids are recognized by a . . .
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