Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway

HIGHLIGHTS

  • who: Jihui Ren from the DepartmentUniversity, Stony Brook, NY have published the article: Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway, in the Journal: (JOURNAL)
  • what: This study shows SPT can utilize both serine and alanine to generate canonical and noncanonical SPLs with the serine influx at a faster rate than alanine influx. The in_vivo labeling assay with deuterated serine or alanine used in this study showed different dynamics for SPT utilization of the two amino_acid substrates with a much slower incorporation rate for alanine, which also . . .

     

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