A new pathway of cd5 glycoprotein-mediated t cell inhibition dependent on inhibitory phosphorylation of fyn kinase*

HIGHLIGHTS

• who: Martina Bamberger from the (UNIVERSITY) have published the paper: A New Pathway of CD5 Glycoprotein-mediated T Cell Inhibition Dependent on Inhibitory Phosphorylation of Fyn Kinase*, in the Journal: (JOURNAL) of February/14,/2011
• what: In the present report the authors show that CD5 may also inhibit cell activation through a parallel and previously undescribed mechanism involving the phosphorylation of Fyn at the C-terminal inhibitory tyrosine, thus reducing the activity of this kinase.
• how: Similar results were obtained with PBMC in resting cells all detectable CD5 is in the soluble fraction . . .
  

   

  

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