Synthetic strategies of pyrimidine-based scaffolds as aurora kinase and polo-like kinase inhibitors

HIGHLIGHTS

  • who: Mrunal Jadhav and colleagues from the Department of Pharmaceutical Chemistry and Quality Assurance, SVKM's DrBhanuben Nanavati College Department of Pharmaceutical Chemistry, College of Pharmacy and Health Sciences, Ajman University have published the Article: Synthetic Strategies of Pyrimidine-Based Scaffolds as Aurora Kinase and Polo-like Kinase Inhibitors, in the Journal: Molecules 2021, 26, 5170. of 17/07/2021
  • what: This study showed that LiHMDS salt base is effective for deprotonating α-H on a 3-phenylpropionitrile substrate.

SUMMARY

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