Activating transcription factor 4-dependent hsa-mir-663a transcription mediates mtorc1/p70s6k1 signaling underleucine deprivation

HIGHLIGHTS

  • who: Huijuan Jia and Hisanori Kato from the Hefei University of, China have published the research work: Activating transcription factor 4-dependent hsa-miR-663a transcription mediates mTORC1/p70S6K1 signaling underleucine deprivation, in the Journal: (JOURNAL)
  • what: The authors identified two miRNAs (hsa-miR-663a and hsa-miR1469) that were upregulated by both ATF4 signals and leucine deprivation. hsa-miR-663a was previously implicated in immune_response regulation and has shown to be associated with several disorders and diseases, including systematic lupus erythematosus and ovarian cancer . hsa-miR-1469 was reported to be p53-responsive; thus . . .

     

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