HIGHLIGHTS
- who: TRIM and colleagues from the France University of Padua, Italy have published the Article: TRIM21, a New Component of the TRAIL-Induced Endogenous Necrosome Complex, in the Journal: (JOURNAL)
- how: In this study the combination of TRAIL/z-VADfmk/Birinapant (TzB) was used to better characterize the necroptotic death signal induced by TRAIL. These data showed that TRIM21 is a new positive modulator of TRAIL-induced necroptosis. In this work TRAIL treatment in combination with z-VADfmk (a pan-caspase inhibitor) and Birinapant (a pan-IAP inhibitor) (TzB) was used to induce necroptosis in . . .
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