HIGHLIGHTS
- who: Julien Robert-Paganin from the Research University have published the paper: Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors focused on three converter mutations for 4 which single-molecule studies had been performed. There are two main differences in the sequestered model the authors propose compared to previous models: (i) the motor domain coordinates are much improved and reliable since the molecular dynamics have optimized the overall geometry of the model and the intramolecular interactions that occur upon . . .
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