Methionine cycle rewiring by targeting mir-873-5p modulates ammonia metabolism to protect the liver from acetaminophen

HIGHLIGHTS

• who: Rubén Rodríguez-Agudo and colleagues from the Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research , Derio, Spain Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine have published the article: Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen, in the Journal: (JOURNAL) of 10/03/2022
• what: The authors demonstrate a GNMT and methionine cycle activity restoration by the anti-miR-873-5p that reduces mitochondrial dysfunction and oxidative stress. This work evaluates perturbations in ammonia . . .
  

   

  

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