Itch induced by peripheral mu opioid receptors is dependent on trpv1-expressing neurons and alleviated by channel activation

HIGHLIGHTS

• who: Helvira Melo from the C BL/6, month old male mice (25, g) were used in the studyPreliminary data showed that both male and female exhibited DAMGO-induced itch similarly, and both sexes were therefore grouped in the analysis. Animals were obtained from Jackson Laboratories and maintained at a controlled temperature (, ± , °C) with free access to food and water and with a, dark-light cycle. The , KO mice were bred at the University of Calgary. The , and mast cell (Kit-Wsh/Wsh) knock out and their control littermates were bred at the University of Calgary (Drs . . .
  

   

  

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