Exposure to factor viii protein in the presence of phosphatidylserine induces hypo-responsiveness toward factor viii challenge in hemophilia a mice*

HIGHLIGHTS

• who: Puneet Gaitonde from the (UNIVERSITY) have published the paper: Exposure to Factor VIII Protein in the Presence of Phosphatidylserine Induces Hypo-responsiveness toward Factor VIII Challenge in Hemophilia A Mice*, in the Journal: (JOURNAL) of June/14,/2013
• what: The studies aimed at understanding the mechanism of this reduction showed that FVIII-PS down-regulated the expression of CD40 upon exposure to bone marrow-derived dendritic cells (DC) .
• how: The complexes were tested for endotoxin level by using the Endosafe Endochrome-K endotoxin assay kit (Charles River Laboratories International) and endotoxin negative . . .
  

   

  

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