An autoregulatory loop between nrf2 and cul3-rbx1 controls their cellular abundance*

HIGHLIGHTS

• who: James W. Kaspar from the James WKaspar and Anil K. Jaiswal, From the Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland , The INrf, (Keap1)/Cul3-Rbx, complex constantly degrades Nrf, under normal conditions. When a cell encounters oxidative or electrophilic stress, Nrf, dissociates from the INrf2/ Cul3-Rbx, complex and translocates into the nucleus. In the nucleus, Nrf, activates a myriad of antioxidant and defensive genes that protect cells. Nrf, is then exported out of the nucleus and degraded. INrf, serves as a substrate adaptor to link Nrf, to Cul . . .
  

   

  

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