Wild-type and brachyolmia-causing mutant trpv4 channels respond directly to stretch force*

HIGHLIGHTS

  • who: Stephen Loukin from the (UNIVERSITY) have published the Article: Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force*, in the Journal: (JOURNAL) of August/27,/2010
  • what: The authors report that TRPV4 is in fact directly mechanosensitive.
  • how: The authors conducted an extensive analysis of the brachyolmiacausing R616Q allele and found it to have an increased constitutive activity but also to display direct force activation.

SUMMARY

    In stark contrast with vision, smell, and most tastes, which are based on G-protein-coupled receptors, the . . .

     

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