Coordinate regulation of yeast sterol regulatory element-binding protein (srebp) and mga2 transcription factors*

HIGHLIGHTS

• who: from the Risa Burr, Emerson VStewart, and X Peter J. Espenshade, From the Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland , Edited by Dennis R. Voelker The Mga, and Sre, transcription factors regulate oxygen-responsive lipid homeostasis in the fission yeast Schizosaccharomyces pombe in a manner analogous to the mammalian sterol regulatory element-binding protein (SREBP), and , transcription factors. Mga, and , regulate triacylglycerol and glycerophospholipid synthesis, whereas Sre, and , regulate sterol synthesis. In mammals, a shared activation mechanism allows for coordinate regulation of , and SREBP-2. In contrast, distinct pathways activate . . .
  

   

  

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