Aryl hydrocarbon receptor plays protective roles against high fat diet (hfd)-induced hepatic steatosis and the subsequent lipotoxicity via direct transcriptional regulation of socs3 gene expression*

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• who: Taira Wada from the Taira Wada, Hiroshi Sunaga, Kazuki Miyata, Haruno Shirasaki, Yuki Uchiyama, and Shigeki Shimba, From the Department of Health Science, School of Pharmacy, Nihon University, Funabashi, Chiba, Japan Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor regulating the expression of genes involved in xenobiotic responseRecent studies have suggested that AhR plays essential roles not only in xenobiotic detoxification but also energy metabolism. Thus, in this study, we studied the roles of AhR in lipid metabolism. Under high fat diet (HFD) challenge, liver-specific AhR knock-out (AhR LKO) mice exhibited severe . . .
  

   

  

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