P38γ and δ promote heart hypertrophy by targeting the mtor-inhibitory protein deptor for degradation

HIGHLIGHTS

• who: Bá and colleagues from the Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNIC, Madrid, Spain, Hospital de La Princesa, Madrid, Spain. have published the Article: p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 22/01/2016
• what: The authors show that cardiac activation of p38g and p38d increases during postnatal development and by hypertrophy-inducing stimuli. p38g/d promote cardiac hypertrophy by phosphorylating the mTORC1 and mTORC2 inhibitor DEPTOR which leads to its degradation and mTOR activation . . .
  

   

  

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