Chaperone addiction of toxin–antitoxin systems

HIGHLIGHTS

• who: Patricia Bordes from the Molecular Biosciences, Northwestern University, Evanston, Illinois, USA have published the paper: Chaperone addiction of toxin–antitoxin systems, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 12/02/2016
• what: The authors show that TAC antitoxins possess a short chaperone addiction sequence, named ChAD, at their carboxy-terminal end, which efficiently prevents antitoxin folding and specifically recruits the SecBTA chaperone.
• how: The authors have used the TAC system of M. tuberculosis as a model to shed light on the molecular mechanism that renders TA pairs chaperone-dependent. The mutants . . .
  

   

  

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