Saturation of acyl chains converts cardiolipin from an antagonist to an activator of toll-like receptor-4

HIGHLIGHTS

• who: Malvina Pizzuto from the Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge , GA, UK have published the article: Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4, in the Journal: (JOURNAL)
• what: The authors show that unsaturated but not saturated CLs block LPS-induced NF-κB activation TNF-α and IP-10 secretion in human and murine macrophages as well as LPS-induced TNF-α and IL-1β release in human blood mononuclear cells. Using HEK293 cells transfected with Toll-like receptor 4 (TLR4) and its . . .
  

   

  

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