The inflammasome adapter asc assembles into filaments with integral participation of its two death domains, pyd and card

HIGHLIGHTS

• who: Reinard Jeffrey T. Nambayan from the (UNIVERSITY) have published the research work: The inflammasome adapter ASC assembles into filaments with integral participation of its two Death Domains, PYD and CARD, in the Journal: (JOURNAL) of June/10,/2018
• what: The authors show that ASC forms ⬃6 -7-nm-wide filaments that stack laterally to form bundles. The authors show that filament and filament stacking can be controlled by pH, pointing to a potential role of pH in inflammasome assembly. The authors show by solution NMR that ASCCARD, while folded as a six-helix bundle . . .
  

   

  

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