HIGHLIGHTS
- who: Carolin Schmidtke from the Antibodies and materials The following antibodies were used: mouse anti-␣-tubulin (Sigma-Aldrich) have published the paper: Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking, in the Journal: (JOURNAL) of April/12,/2019
- what: Consistent with these observations, the authors show here that in Cln3⌬ex7/8 cells the transport efficiency of two endocytic cargo receptors, the Mpr300 and TrfR, is affected by two different mechanisms: alteration of the steady-state receptor protein concentration (Mpr300) (Fig 3, B and C . . .
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