Plasma membrane cholesterol as a regulator of human and rodent p2x7 receptor activation and sensitization*

HIGHLIGHTS

• who: Lucy E. Robinson from the Lucy ERobinson1, Mitesh Shridar2, Philip Smith, and Ruth D. Murrell-Lagnado, From the Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge , PD, United Kingdom Background: P , receptors are important in inflammation and immunity, but excessive activation results in cell death. Results: Facilitation of P , receptor currents and dilation of the pore are enhanced by cholesterol depletion and reduced by cholesterol loading. Conclusions: Plasma membrane cholesterol destabilizes the open and dilated states of the receptor pore. Significance: Targeting of P , to cholesterol-rich lipid rafts may protect cells from death . . .
  

   

  

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