Identification of ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling

HIGHLIGHTS

• who: Wookjin Shin from the Human, Ras, Ras, and, Ras cDNA fragments were cloned into the pcDNA31-Myc vector in a previous study23. The substitution of human, Ras threonines , and , to alanines (T144/, A) was described in a previous study20. The pFA2-Elk-1, pFR-Luc, and pCMVβ-gal reporter plasmids were used for Elk, reporter assays23. The pEGFP-, and pEGFP-K-RasG V plasmids were provided by Dr. Yoel Kloog (Tel-Aviv University, Tel-Aviv, Israel). EGFP and EGFP-K-RasG V cDNA fragments were cloned into the pLVX-IRES-Hygro (Clontech, Mountain View, CA, USA . . .
  

   

  

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