The e3 ubiquitin ligase march2 regulates ergic3-dependent trafficking of secretory proteins

HIGHLIGHTS

• who: Wonjin Yoo from the (UNIVERSITY) have published the research: The E3 ubiquitin ligase MARCH2 regulates ERGIC3-dependent trafficking of secretory proteins, in the Journal: (JOURNAL) of May/17,/2019
• what: The authors report that MARCH2 directs ubiquitination and subsequent degradation of ERGIC3 and that MARCH2 depletion increases endogenous ERGIC3 levels. The authors provide evidence that the lysine residues at positions 6 and 8 of ERGIC3 are the major sites of MARCH2-mediated ubiquitination. The authors provide novel insight into the MARCH2-mediated regulation of protein secretion.
• how: Taken together these results indicated . . .
  

   

  

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