Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

HIGHLIGHTS

• who: Yingguo Liu from the School Technological University have published the Article: Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The main reasons likely include lower nucleophilicity of the trifluoracetic anion, and the poor stabilities of the intermediates resulted from reactions between trifluoracetic anion and the dialdehyde substrates.

SUMMARY

To date, phthalidyl esters are routinely prepared via reactions of carboxylic acids with 3bromophthalides (Fig 1b)16. The phthalidyl esters are afforded as a racemic_mixture of two enantiomers. The . . .

 



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