Oxidative inactivation of mitochondrial aconitase results in iron and h o -mediated neurotoxicity in rat primary mesencephalic cultures

HIGHLIGHTS

• who: David Cantu et al. from the Neuroscience Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America, Department of Microbiology, University have published the article: Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H O -Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures, in the Journal: (JOURNAL) of September/18,/2009
• what: The aim of this study was to determine if oxidative inactivation of mitochondrial aconitase (m-aconitase) resulted in the release of redox-active iron (Fe2+) and hydrogen peroxide (H2O2) and whether this contributes to cell death. The authors . . .
  

   

  

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