Characterization of the loss of sumo pathway function on cancer cells and tumor proliferation

HIGHLIGHTS

• who: Xingyue He et al. from the (UNIVERSITY) have published the Article: Characterization of the Loss of SUMO Pathway Function on Cancer Cells and Tumor Proliferation, in the Journal: PLOS ONE | DOI:10.1371/journal.pone [0123882]. April 10, 2015 of November/24,/2014
• what: The authors showed that SUMO E1 and E2 shRNAs reduced SUMO pathway activity measured by cell based reporter assay and SUMO conjugate immunoblots. The studies demonstrate that acute SAE2 knockdown in human cancer cells induces mitotic defects, endoreduplication and multinucleation leading to cellular senescence and apoptosis. Data presented in this . . .
  

   

  

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