Snca triplication parkinson’s patient’s ipsc-derived da neurons accumulate a -synuclein and are susceptible to oxidative stress

HIGHLIGHTS

• who: Blake Byers et al. from the Department of Bioengineering, Stanford University, Stanford, California, United States of America, Institute for Stem Cell Biology and Regenerative Medicine, Stanford have published the research work: SNCA Triplication Parkinson’s Patient’s iPSC-derived DA Neurons Accumulate a -Synuclein and Are Susceptible to Oxidative Stress, in the Journal: (JOURNAL) of November/16,/2011
• what: The authors report the generation of iPSCderived midbrain dopaminergic neurons from a patient with a triplication in the a-synuclein gene (SNCA).

SUMMARY

Although overexpression of a-synuclein transgenes leads to . . .

 



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