HIGHLIGHTS
- who: PLoS BIOLOGY and collaborators from the DepartmentsColumbia University have published the Article: DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits a -Synuclein Aggregate Formation, in the Journal: (JOURNAL)
- what: In a companion Article (Martinat et_al 2004) the authors show mutations in DJ-1 alter the cellular response to oxidative stress and proteasomal inhibition. The authors show DJ-1 functions as a redoxsensitive molecular is activated in an oxidative cytoplasmic environment. The authors demonstrate that DJ-1 chaperone activity is inhibited by reducing conditions, and can be stimulated by oxidation.
- how . . .
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