Multivalent histone and dna engagement by a phd/brd/pwwp triple reader cassette recruits zmynd8 to k14ac-rich chromatin

HIGHLIGHTS

• who: Pavel Savitsky from the University of UK have published the research: Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin, in the Journal: (JOURNAL)
• what: Alanine mutations (guided by the model shown in A) introduced on the PHD/BRD (RKKK/AAAA) or the PWWP (KKK/AAA) interface abolish DNA interactions in EMSAs. The authors report the structure of the triple N-terminal reader modules found in ZMYND8, which form a stable ensemble capable of simultaneously engaging histones and DNA. The authors show that perturbation . . .
  

   

  

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