Parallel genome-wide screens identify synthetic viable interactions between the blm helicase complex and fanconi anemia

HIGHLIGHTS

• who: Martin Moder from the Austrian Academy of University of have published the paper: Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors report that when members of both complexes are absent, ICL lesions can be channeled through alternative repair pathways, at the cost of genome integrity.
• how: For both genome-wide screens the CRISPR-Cas9 mediated editing and insertional mutagenesis screen the authors used human haploid HAP1 cells since the likelihood to receive loss-of . . .
  

   

  

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