Ras oncogene-mediated progressive silencing of extracellular superoxide dismutase in tumorigenesis

HIGHLIGHTS

  • who: Francesca Cammarota and collaborators from the IRCCS SDN, Naples, Italy Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy have published the Article: Ras Oncogene-Mediated Progressive Silencing of Extracellular Superoxide Dismutase in Tumorigenesis, in the Journal: (JOURNAL) of 15/06/2015
  • what: The authors studied the mechanisms regulating SOD3 expression in vitro using thyroid cell models representing different stages of thyroid cancer. The authors demonstrate that a low level of RAS activation increases SOD3 mRNA synthesis that then gradually decreases with increasing levels of RAS activation and the . . .

     

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