Smooth muscle tension induces invasive remodeling of the zebrafish intestine

HIGHLIGHTS

  • who: Christoph Seiler et al. from the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Physiology, Institute for have published the research work: Smooth Muscle Tension Induces Invasive Remodeling of the Zebrafish Intestine, in the Journal: (JOURNAL) of May/14,/2012
  • what: The authors show that epithelial cell invasion in the intestine of zebrafish meltdown (mlt) mutants arises in response to unregulated contractile tone in the surrounding smooth muscle cell layer. The physical signal arising from increased contractile tone activates a feed forward redox signaling loop . . .

     

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