Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via clec16a-, bax-, and gsh- pathways

HIGHLIGHTS

• who: Chenyang Duan from the Sprague-Dawley (SD) rats were purchased from Army Medical University (Chongqing, China) and Drp, KO mice (Drp1±) were generated by Shanghai Model Organisms Center, Inc(Shanghai, CHINA). The Mouse Genome Informatics (MGI) database (http://www. informatics.jax.org) showed that mice homozygous for the knockout Drp, allele exhibit embryonic lethality. The frameshift and functional loss of the Drp, gene reading frame was achieved by CRISPR/Cas, and nonhomologous recombination repair to pull in the mutation and obtain Cas, mRNA/gRNA. , Drp, KO mice generation was obtained afterwards. The transcript Ensembl for Drp . . .
  

   

  

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