Canagliflozin inhibits growth of hepatocellular carcinoma via blocking glucose-influx-induced β-catenin activation

HIGHLIGHTS

• who: Man-Hsin Hung from the approved by the Institutional Laboratory Animal Care and Use Committee of National Taiwan UniversityIn brief, Huh7-xenograft tumors were inoculated subcutaneously on the flank of each mouse with a mixture of , × , cancer cells suspended in, ., ml of serum-free medium containing, % Matrigel (BD Biosciences, Bedford, MA). For CANA treatment, because of the lack of literature demonstrating the appropriate dose of CANA, we designed a two-stage dosing plan. At the first dose stage, mice were fed with CANA , mg/kg/day, this was increased up to , mg/kg/day in the . . .
  

   

  

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